- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Buspirone is an azapirone anxiolytic that acts as a partial agonist at 5-HT1A receptors and α1-adrenergic receptors and an antagonist at D2/3/4 receptors. Buspirone is clinically used to treat anxiety. In animal models, buspirone inhibits MMPP-induced enhancements in memory acquisition and formation.
Product Info
33386-08-2 |
≥98% |
C21H31N5O2 • HCl |
421.97 |
8-[4-[4-(2-Pyrimidinyl)=1=piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride |
Anisal; Axoren; Bespar; Buspinol; Narol |
201.5-202.5°C |
Soluble in water. |
White powder |
Shipping and Storage
4°C |
Ambient |
Downloads
B8274 MSDS PDF |
B8274 Info Sheet PDF |
References
Navarrete A, Flores-Machorro FX, Téllez-Ballesteros RI, et al. Study on action mechanism of 1-(4-methoxy-2-methylphenyl)piperazine (MMPP) in acquisition, formation, and consolidation of memory in mice. Drug Dev Res. 2014 Mar;75(2):59-67. PMID: 24648132.
Loane C, Politis M. Buspirone: what is it all about? Brain Res. 2012 Jun 21;1461:111-8. PMID: 22608068.
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